Open-source model

The IPECAD Alzheimer’s disease model (Green et al, 2019) has been developed by the IPECAD Modelling Group as a framework to model disease progression across Alzheimer’s disease (AD) and to assess the costs and outcomes associated with the condition, and the cost-effectiveness of interventions for people affected by AD, using the scenario of a future disease modifying therapies (DMT) for people with mild cognitive impairment (MCI) due to AD.

A description of the model (version 1.0) entitled “Assessing cost-effectiveness of early intervention in Alzheimer’s disease: An open-source modeling framework” is published open-access in the journal Alzheimer’s and Dementia: the journal of the Alzheimer’s Association (Alzheimers Dement 2019 Oct;15(10):1309-1321 doi: 10.1016/j.jalz.2019.05.004 or PubMed).

You can use this open-source model for free under the Creative Commons Attribution-ShareAlike 4.0 International Public License.

We host a version history developed by the IPECAD Modelling Group below.

We provide a listing of self-reported external applications of the model below to endorse transparency.

Request a download link


External applications & involvements

2020 October: publication Jun H, Cho SK, Aliyev ER, Mattke S, Suen SC. How Much Value Would a Treatment for Alzheimer’s Disease Offer? Cost-Effectiveness Thresholds for Pricing a Disease-Modifying Therapy. Curr Alzheimer Res. 2020 Dec 3. doi: 10.2174/1567205017666201203121907. PMID: 33272181

2020 October: Bengt Winblad (IPECAD member) has provided general advise for Grifols International – AMBAR commercial Development who have requested the IPECAD model version 1.0.

2020 May-August: Ron Handels (IPECAD member) has guided two master students who have applied the IPECAD model version 1.0 in their internship (Health, Policy and Management master’s program at Maastricht University).

Version history

Version 1.0

Modelling group

left to right: Bengt Winblad, Colin Green, Ron Handels, Anders Wimo, Anders Sköldunger, Anders Gustavsson, Linus Jönsson

Anders Gustavsson (Karolinska Institutet, Sweden)

Colin Green (University of Exeter, UK)

Ron Handels (Karolinska Institutet, Sweden; Maastricht University, Netherlands)

Linus Jönsson (Karolinska Institutet, Sweden)

Andreas Karlson (Karolinska Institutet, Sweden)

Anders Sköldunger (Karolinska Institutet, Sweden)

Anders Wimo (Karolinska Institutet, Sweden)

Bengt Winblad (Karolinska Institutet, Sweden)

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